Special Toxicity Study

As a world-leading service provider for drug discovery and safety assessment, Creative Biolabs has successfully established a panel of state-of-art technologies for exploiting special toxicity study. We have accumulated extensive experience from the accomplishment of different projects, during which we have received a lot of recognition and praise from our clients. Now, we are happy to introduce our special toxicity study services for investigating the efficacy and safety of candidate drugs.

Introduction to Special Toxicity Study

Toxicity study of candidate drugs plays an important role in evaluating the safety before the clinical trial. The early risk assessment of compound or test article is a critical part of the whole drug development pipeline. Recent studies have demonstrated that the safety evaluation assays have been considered as a powerful tool for identifying the right compounds and reducing the costs in drug development. In order to better predict potential risks and reduce unnecessary drug discovery costs, more emphasis needs to be placed on an accurate assessment of potential risks in the early stages of development. Therefore, Creative Biolabs has developed a panel of assays for offering In Vitro Safety Pharmacology Studies services to support candidate selection and IND application of new drugs. Meanwhile, the comprehensive special toxicity study platform will meet any requirements of your project. In addition, our integrated scientists can explain your results and design the suitable tests to further advance your program.

Fig.1 Overview of drug discovery screening assays. (Hughes, 2011)

The services of Special Toxicity Study

Based on the requirements of toxicity study in drug development, Creative Biolabs can offer a full range of tests to measure the safety and toxicity of any potential compounds, including but not limited to:

• Genotoxicity Study

Creative Biolabs offers a series of genotoxicity services to measure the genotoxicity of test article. The data will help you understand the potential risk of candidate drugs and reveal the pathogenesis of DNA damage. The study consists of the Ames test, in vitro chromosomal analysis as well as in vitro comet assay.

• Carcinogenicity Studies

Creative Biolabs provides the services of in vitro carcinogenicity studies to estimate the carcinogenic potential of compounds or agents. Our carcinogenicity studies are cost-effective and time-saving assays that can screen various chemicals in a high-throughput manner. Additionally, a variety of in vitro models have been established to meet the special needs of our clients.

• Reproductive Toxicity Study

At Creative Biolabs, we have developed a panel of assays for detecting the toxicity of candidate drugs to reproduction system. The embryonic stem cell test (EST) is the most common method for evaluating reproductive toxicity before the clinical trial. In addition, we can also offer the services of the ReProTect test for reproductive toxicity testing.

• Drug Dependence

Drug dependence has been regarded as a major concern for morbidity in human. We can assist our clients to study the mechanisms of drug dependence at the cellular and molecular level. Furthermore, we can offer in vitro tests for evaluating the drug dependence of compounds.

Fig.2 Effects of MIL-100(Fe) on apoptosis in HL-7702 cells. (Chen, 2019)

With the help of abundant experience and professional scientists, Creative Biolabs is committed to guiding global customers to a series of drug discovery solutions. We are always dedicated to assisting our clients with the most satisfactory drug development services on in vitro safety evaluation. If you are interested in our services, please feel free to contact us or send us an inquiry.

References

1. Hughes, J. P., et al. Principles of early drug discovery. Br J Pharmacol. 2011, 162(6): 1239-49.
2. Chen, G., et al. In Vitro Toxicity Study of a Porous Iron(III) Metal-Organic Framework. Molecules. 2019, 28: 24(7).

For Research Use Only.