Infusion Toxicology

Infusion toxicology studies in one or more toxicologically relevant species support the preclinical safety assessment of drugs intended for intravenous administration in humans. Infusion toxicology in humans helps researchers achieve a constant systemic exposure which can produce desired pharmacological effect with the minimum adverse effects. The aims of infusion toxicology study in animals are mimicking the proposed clinical administration route and helping establish safety margins in relation to the clinical dosing regimen.

Creative Biolabs has extensive experience in infusing toxicity study with a variety of dosing routes and well-established infusion models. The infusion toxicology studies are either intermittent or continuous, and the ambulatory and tethered infusion systems use indwelling catheters, percutaneous catheters or vascular access ports. With our in-depth knowledge and well-equipped surgical suite, we are able to custom design experiments to incorporate the most appropriate application of infusion technology to meet research needs or regulatory requirements.

Creative Biolabs have the features with

• PhD-level certified pathologists
• Extensive experience to ensure optimal selection of vehicles, formulation conditions, pH, osmolality, and maximum/minimum dose volumes.
• Customized studies designed to incorporate your specific research requirements
• GLP certified, AAALAC and CCAC accredited facilities
• Computerized environmental control and monitoring system
• Purpose-built surgical suites for catheter implantation according to the highest standards
• On-site bioanalytical laboratory for the prompt analysis
• Flexible, collaborative approach to ensure test reliability, high quality, timeliness, and cost-effectiveness.

Our capabilities

• Design studies involving both intravenous and subcutaneous infusion, including:
• Target tissue dosing (e.g. cerebrospinal delivery into the intrathecal)
• Efficacy studies by infusion into tumor-bearing animals
• Dosing and sampling via dual vascular catheterization
• Peritoneal fluid exchanges

• Infusion toxicology in both intermittent and continuous infusion models, utilizing current technologies

• Ambulatory and tethered infusion systems using:
• Indwelling catheters
• Percutaneous catheters
• Vascular access ports
• Tail vein infusion
• Ear vein infusion

• A complete GLP infusion toxicology studies in both small and large animals
• Mice
• Rats
• Rabbits
• Guinea pigs
• Dogs
• Mini pigs
• Nonhuman primates

Supporting Equipment and Facilities

• Surgical suites for on-site cannulation
• Protective jackets with secure pump systems
• Micro infusion pumps
• Special delivery techniques

• Jacket-tether or ambulatory infusion systems
• Laminar flow hoods for parenteral product preparation
• Large capacity autoclaves
• Imaging laboratory

Depending on study needs, we can perform acute to chronic studies requiring infusions of minutes or hours to continuous (24-hour) and for up to 24-month duration using indwelling or peripheral catheters. A variety of delivery methods ranging from slow bolus techniques to intermittent and continuous dosing is available.

We have extensive knowledge and experience and provide comprehensive and one-stop animal toxicity test services. For more detailed information, please feel free to contact us or directly sent us an inquiry.

For Research Use Only.