As a leading company in the field of preclinical safety evaluation, Creative Biolabs has gained a wealth of experience in numerous toxicology studies. With advanced technology and professional scientists, now we can provide a comprehensive package of ocular toxicology services for global customers to promote vision-related drug development. We are happy to share our experience and specific advice with our customers all over the world.

Importance of Ocular Toxicity Evaluation

As an assembly of many specialized sub-organs which have specific functions, the eye plays an important role in daily life as human commonly obtain approximately 80% of external information from vision. Once a part of integrity functions is lost, overall function of the eye might be disturbed. It has been reported that numerous systemic medications have the ability to induce permanent visual loss. Therefore, it is an important part of ocular toxicity evaluation in preclinical development. Especially, ocular-related drug development requires both systemic and local characterization.

Ocular Toxicity Services Provided by Creative Biolabs

With abundant experience and latest technology, Creative Biolabs is capable of offering professional solution and expert advice for your vision-related drug development. Apart from common ocular toxicity tests, such as eye corrosives and eye irritants, we also offer other ophthalmology models and endpoints for your ocular drug program development in compliance with GLP or non-GLP regulations. The services available at Creative Biolabs following as below:

  • Electroretinography (ERG)
  • Tonometry (IOP) evaluations
  • Pachymetry
  • Specular microscopy for noninvasive
  • Fundus photography (digital and video)
  • Fundus autofluorescence
  • Ocular and systemic tissue distribution
  • Ocular surgery/implant
  • Ocular histology/pathology and clinical support
  • Pachymetry (corneal thickness)
  • Optic nerve damage assessment
  • Vitrectomy

With experienced scientists, our ocular toxicity studies can be conducted through various administration routes, which including but not limited to:

  • Intravitreal injection
  • Anterior chamber injection
  • Subconjunctival injection
  • Subretinal injection

Ocular ToxicityFig.1 (A) Anatomic drawing of supporting structures of the eye and classes of anticancer drugs associated with toxicity. (B) Anatomic drawing of the eye and classes of anticancer drugs associated with eye toxicity. (Renouf D J, et al. 2012)

Including ocular toxicity service, Creative Biolabs provides various preclinical toxicology evaluation services for our global customers. We are happy to offer our clients with one-stop service through our in-house analytical support in a quick and cost-effective way. To learn more about the toxicology services we can provide, please click the links below.

Creative Biolabs is committed to being your good partner in the process of IND-enabling development. If you are interested in the service we offer, please don't hesitate to contact us or directly sent us an inquiry.

Reference

  1. Renouf D J, et al. Ocular toxicity of targeted therapies [J]. Journal of Clinical Oncology, 2012, 30(26): 3277-3286.

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