AccuMetab™ Human CYP51 Enzyme, Catalytically Active

CAT#: ITS-0426-YL31
Product Type: Recombinant Phase I Metabolizing Enzyme
Brand: AccuMetab
Development Stage: ADME
ADME Research Domain: Metabolism
Short Description
Human CYP51 for accurate Phase I drug metabolism profiling.
Brand
AccuMetab
Development Stage
ADME
ADME Research Domain
Metabolism
Background
Functioning as lanosterol 14-alpha-demethylase, CYP51 is a universally conserved enzyme critical for mammalian cholesterol biosynthesis. In drug discovery, it is heavily utilized as a primary target for sterol-inhibiting drugs and as a necessary safety counter-screen for novel antifungal agents.
Key Features
Conserved lanosterol 14-alpha-demethylase; Primary target for sterol-inhibiting drugs; Safety counter-screen for antifungal agents; Supplied in robust, high-reductase formats
Applications
Drug Metabolism Studies, Reaction Phenotyping, DDI Assessment, Metabolite ID
Research Areas
ADME; Drug-Drug Interactions (DDI)
Species
Human
Expression System
Recombinant enzymes prepared from E. coli and co-expressed with NADPH CYP-reductase.
Physical Form
Liquid
Size
0.5 nmol; 1 nmol; 4 nmol; 10 mg
Storage
-80°C
Storage Comment
When stored at -80°C, our product remains stable and retains full functional activity for up to 10 years.
Note
For bulk pricing or custom reagent inquiries, please contact us by email or phone. Products are shipped on ice via FedEx.
Restrictions
For Research Use Only (RUO). Not intended for diagnostic or therapeutic use.
Shipping
Our enzyme products are shipped at -80°C.
For Research Use Only | Not For Clinical Use
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