GlycoErase™ GSK3B Knockout HEK293T Cell Line (CAT#: GLJF-0825-JF521)

Description	GlycoErase™ GSK3B knockout HEK293T cell line is a human HEK293T model in which GSK3B has been removed. GSK3B encodes a multifunctional kinase that negatively regulates glucose homeostasis and participates in inflammatory signaling, mitochondrial function, ER stress, and apoptosis. Genetic associations link GSK3B to Alzheimer's and Parkinson's diseases. This knockout provides a tractable system to study neurodegenerative disease pathways, metabolic regulation, and inflammatory signaling in a human background, supporting neuroscience and translational medicine research.
Product Type	KO Cell Lines
Species	Human
Cell Morphology	Epithelial-like, adherent
Passage Ratio	1:2~1:4
Cell Line	HEK293T
Lineage	Embryonic kidney

Cell Viability	>90%
Sterility Test	The sterility test indicated an absence of microbial growth.
Identity Test	STR identification
Mycoplasma Test	Negative
Virus Test	Negative for HIV, HBV and HCV.
Genetic Stability Testing	We conduct cell genetic stability studies in full compliance with ICH guidelines. Our expertise enables us to design and execute a comprehensive testing program tailored to your specific needs and regulatory requirements.
Validation	PCR, Sanger Sequencing
Culture Medium	DMEM & FBS & Penicillin/Streptomycin
Application	Functional assay
Size	1 M cells/vial*2
Product Format	Frozen
Shipping	Dry ice
Availability Status	Made to order
Handling Notes	Upon receipt, this product must be immediately transferred from dry ice to liquid nitrogen (-150°C to -190°C) and stored in a liquid nitrogen tank. Cell viability is critically dependent on proper handling. We cannot guarantee viability if these instructions are not strictly adhered to.
Product Disclaimer	This product is provided for research only, not suitable for human or animal use. Due to the inherent limitations of infectious agent testing, investigators must exercise extreme caution when handling cells provided by Creative Biolabs, treating all cells as potentially biohazardous.

Target	GSK3B
Full Name	Glycogen Synthase Kinase 3 Beta
Location	3q13.33
Gene ID	2932
Summary	This gene encodes a serine-threonine kinase in the glycogen synthase kinase family. It regulates glucose homeostasis, inflammation, and apoptotic pathways, with defects linked to Parkinson's and Alzheimer's diseases.