GlycoErase™ HEK293T ST6GALNAC1 Knockout Cell Line (CAT#: GLJF-0425-JF478)

Description	To further expand the tools available for studying sialylation, we are pleased to offer an ST6GALNAC1 knockout HEK293T cell line. This model lacks the ST6GALNAC1-encoded ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 1, an enzyme involved in the sialylation of glycoproteins and glycolipids. The absence of ST6GALNAC1 function in this cell line provides a unique opportunity to investigate the role of sialylation in cell-cell interaction, matrix interactions, and intracellular signaling.
Product Type	KO Cell Lines
Species	Human
Cell Morphology	Epithelial-like, adherent
Passage Ratio	1:2~1:4
Cell Line	HEK293T
Lineage	Embryonic kidney

Cell Viability	>90%
Sterility Test	The sterility test indicated an absence of microbial growth.
Identity Test	STR identification
Mycoplasma Test	Negative
Virus Test	Negative for HIV, HBV and HCV.
Genetic Stability Testing	We conduct cell genetic stability studies in full compliance with ICH guidelines. Our expertise enables us to design and execute a comprehensive testing program tailored to your specific needs and regulatory requirements.
Validation	PCR, Sanger Sequencing
Culture Medium	DMEM & FBS & Penicillin/Streptomycin
Application	Functional assay
Size	1 M cells/vial*2
Product Format	Frozen
Shipping	Dry ice
Availability Status	Made to order
Handling Notes	Upon receipt, this product must be immediately transferred from dry ice to liquid nitrogen (-150°C to -190°C) and stored in a liquid nitrogen tank. Cell viability is critically dependent on proper handling. We cannot guarantee viability if these instructions are not strictly adhered to.
Product Disclaimer	This product is provided for research only, not suitable for human or animal use. Due to the inherent limitations of infectious agent testing, investigators must exercise extreme caution when handling cells provided by Creative Biolabs, treating all cells as potentially biohazardous.

Target	ST6GALNAC1
Full Name	ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 1
Alternative Name	SIAT7A, ST6GalNAcI
Location	17q25.1
Gene ID	55808
Summary	Transfers sialic acid to O-linked GalNAc residues, forming the cancer-associated sialyl-Tn antigen and affecting cell-cell interactions.