Recombinant Human adenovirus C serotype 2 (HAdV-2) Early E3 18.5 kDa glycoprotein (18-123 aa) [His/Myc-Tag], E. coli

Recombinant Human adenovirus C serotype 2 (HAdV-2) Early E3 18.5 kDa glycoprotein (18-123 aa) was expressed in E. coli with a 10xHis-tag at the N-terminus and a Myc-tag at the C-terminus. The biological activity was determined by its binding ability in a functional ELISA. This product can be used in ELISA, WB, IP.

Human adenovirus C serotype 2 (HAdV-2)

18-123 aa

AKKVEFKEPACNVTFKSEANECTTLIKCTTEHEKLIIRHKDKIGKYAVYAIWQPGDTNDYNVTVFQGENRKTFMYKFPFYEMCDITMYMSKQYKLWPPQKCLENTG

10xHis-tag at the N-terminus and Myc-tag at the C-terminus

20.0 kDa

>95%, determined by SDS-PAGE.

Unconjugated

Early E3 18.5 kDa glycoprotein

Early E3 18.5 kDa glycoprotein

This protein binds and retains class I heavy chains in the endoplasmic reticulum during the early period of virus infection, thereby impairing their transport to the cell surface. Also delays the expression of class I alleles that it cannot affect by direct retention. Binds transporters associated with antigen processing (TAP) and acts as a tapasin inhibitor, preventing class I/TAP association. In consequence, infected cells are masked for immune recognition by cytotoxic T-lymphocytes.

E3-19K; E3gp 19 kDa; Short name:; E19; GP19K