To identify the binding site or epitope of an antibody on its target protein (antigen), and to elucidate the mechanism of antibody binding, and to strengthen intellectual property protection, Creative Biolabs is dedicated to epitope binning and mapping service to identify and characterize the antibody binding sites in the discovery and development of new therapeutic antibody product.
We offer high-resolution conformational epitope mapping service for complex proteins and conformational epitopes with >95% success. Our Shotgun Mutagenesis technology can reliably map conformational epitopes at even single amino acid resolution.
| Conformational epitopes | High resolution | Complex proteins | Energetic hot-spots | Speed |
We have extensive experience in highly complex epitopes such as:
|
|
| Co-Crystallography | ✔ | ✔ | ||||
| Peptide Scanning | ✔ | ✔ | ||||
| Epitope Binning | ✔ | ✔ | ||||
| H/D Exchange | ✔ | ✔ | ||||
| Shotgun Mutagenesis Epitope Mapping | ✔ | ✔ | ✔ | ✔ | ✔ |
We offer various types of epitope binning and mapping services to help our clients get the key epitope data of mechanism of action to progress lead candidates, and also protect antibodies via stronger patents.
Fig.1 How will epitope data help you (importance of antibody epitope mapping service).
We are dedicated to seamless end-to-end epitope binning and mapping service on a fee-for-service basis, and all relevant services are available in Creative Biolabs. All final analyzed data will be provided in order to facilitate regulatory and intellectual property filings.
|
① Assay setup according to the specific program |
② Mutagenesis of the target protein |
③ Antibody screening with the designed mutation array |
④ Deliver final report including graphical representation of the epitope data, identification of critical residues, and mapped epitope. |
We have developed several commercial platforms for epitope binning and mapping service to handle binning of a variety of antibodies.
We are always expanding our capabilities, for any other requests, please feel free to contact us.
|
“Our epitope binning and mapping service will greatly support the mechanism of action understanding and the intellectual property claims of our clients’ antibodies which can further facilitate your biologics drug discovery and development.” |
To provide a broad range of options for our clients, Creative Biolabs also offers ELISA and FACS analysis for binning measurements. We aim to be your best trusted partner in biologics discovery and development. Please contact us to learn more.
For Research Use Only | Not For Clinical Use
Download our brochure