GlycoErase™ PEBP1 Knockout HEK293 Cell Line (CAT#: GLJF-0825-JF428)

Description	GlycoErase™ PEBP1 knockout HEK293 cell line is a human embryonic kidney (HEK293) model with PEBP1 expression deleted. PEBP1 encodes phosphatidylethanolamine-binding protein 1, a regulator of MAPK, NF-κB, and GSK3 signaling, and a precursor of hippocampal cholinergic neurostimulating peptide (HCNP). The knockout provides a platform for dissecting neurodevelopmental signaling, cancer metastasis suppression, and MAPK-related therapeutic research.
Product Type	KO Cell Lines
Species	Human
Cell Morphology	Epithelial-like, adherent
Passage Ratio	1:2~1:4
Cell Line	HEK293
Lineage	Embryonic kidney

Cell Viability	>90%
Sterility Test	The sterility test indicated an absence of microbial growth.
Identity Test	STR identification
Mycoplasma Test	Negative
Virus Test	Negative for HIV, HBV and HCV.
Genetic Stability Testing	We conduct cell genetic stability studies in full compliance with ICH guidelines. Our expertise enables us to design and execute a comprehensive testing program tailored to your specific needs and regulatory requirements.
Validation	PCR, Sanger Sequencing
Culture Medium	FBS & Penicillin/Streptomycin & Proline & RPMI
Application	Functional assay
Size	1 M cells/vial*2
Product Format	Frozen
Shipping	Dry ice
Availability Status	Made to order
Handling Notes	Upon receipt, this product must be immediately transferred from dry ice to liquid nitrogen (-150°C to -190°C) and stored in a liquid nitrogen tank. Cell viability is critically dependent on proper handling. We cannot guarantee viability if these instructions are not strictly adhered to.
Product Disclaimer	This product is provided for research only, not suitable for human or animal use. Due to the inherent limitations of infectious agent testing, investigators must exercise extreme caution when handling cells provided by Creative Biolabs, treating all cells as potentially biohazardous.

Target	PEBP1
Full Name	Phosphatidylethanolamine Binding Protein 1
Alternative Name	PBP; HCNP; PEBP; RKIP; HCNPpp; PEBP-1; HEL-210; HEL-S-34; HEL-S-96
Location	12q24.23
Gene ID	5037
Summary	This gene encodes a protein that modulates signaling pathways such as MAPK, NF-kappa B, and GSK-3. It produces a cleavage product, hippocampal cholinergic neurostimulating peptide (HCNP), which is involved in neural development. The gene is implicated in cancer and acts as a metastasis suppressor.