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GlycoErase™ PYGM Knockout HEK293 Cell Line

CAT#: GLJF-0825-JF480

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Overview Specification Target Information Related Products
Overview
Description
GlycoErase™ PYGM knockout HEK293 cell line is a HEK293 model lacking PYGM expression. PYGM encodes muscle glycogen phosphorylase, which supports muscle glycogenolysis. Mutations are associated with McArdle disease, a glycogen storage myopathy. This knockout enables research into glycogen metabolism, energy utilization, and skeletal muscle-linked disorders within a human cell background.
Product Type
KO Cell Lines
Species
Human
Cell Morphology
Epithelial-like, adherent
Passage Ratio
1:2~1:4
Cell Line
HEK293
Lineage
Embryonic kidney
Specification
Cell Viability
>90%
Sterility Test
The sterility test indicated an absence of microbial growth.
Identity Test
STR identification
Mycoplasma Test
Negative
Virus Test
Negative for HIV, HBV and HCV.
Genetic Stability Testing
We conduct cell genetic stability studies in full compliance with ICH guidelines. Our expertise enables us to design and execute a comprehensive testing program tailored to your specific needs and regulatory requirements.
Validation
PCR, Sanger Sequencing
Culture Medium
FBS & Penicillin/Streptomycin & Proline & RPMI
Application
Functional assay
Size
1 M cells/vial*2
Product Format
Frozen
Shipping
Dry ice
Availability Status
Made to order
Handling Notes
Upon receipt, this product must be immediately transferred from dry ice to liquid nitrogen (-150°C to -190°C) and stored in a liquid nitrogen tank. Cell viability is critically dependent on proper handling. We cannot guarantee viability if these instructions are not strictly adhered to.
Product Disclaimer
This product is provided for research only, not suitable for human or animal use. Due to the inherent limitations of infectious agent testing, investigators must exercise extreme caution when handling cells provided by Creative Biolabs, treating all cells as potentially biohazardous.
Target Information
Target
PYGM
Full Name
Glycogen Phosphorylase, Muscle Associated
Alternative Name
GSD5
Location
11q13.1
Gene ID
5837
Summary
This gene encodes the muscle isoform of glycogen phosphorylase, essential for glycogen breakdown in muscle tissue. Variants in this gene result in McArdle disease (myophosphorylase deficiency), a muscle glycogen storage disorder. Alternative splicing produces multiple transcript forms.
For Research Use Only.
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