GlycoErase™ SLC2A4 Knockout HEK293 Cell Line (CAT#: GLJF-0825-JF482)

Description	GlycoErase™ SLC2A4 knockout HEK293 cell line is a HEK293 model lacking SLC2A4 expression. SLC2A4 encodes GLUT4, an insulin-regulated glucose transporter responsible for glucose uptake in adipose and muscle tissue. Dysregulation is associated with insulin resistance and type 2 diabetes. Although not native to kidney-derived cells, the knockout in HEK293 provides a versatile model to study insulin signaling, glucose transport regulation, and metabolic disease pathways.
Product Type	KO Cell Lines
Species	Human
Cell Morphology	Epithelial-like, adherent
Passage Ratio	1:2~1:4
Cell Line	HEK293
Lineage	Embryonic kidney

Cell Viability	>90%
Sterility Test	The sterility test indicated an absence of microbial growth.
Identity Test	STR identification
Mycoplasma Test	Negative
Virus Test	Negative for HIV, HBV and HCV.
Genetic Stability Testing	We conduct cell genetic stability studies in full compliance with ICH guidelines. Our expertise enables us to design and execute a comprehensive testing program tailored to your specific needs and regulatory requirements.
Validation	PCR, Sanger Sequencing
Culture Medium	FBS & Penicillin/Streptomycin & Proline & RPMI
Application	Functional assay
Size	1 M cells/vial*2
Product Format	Frozen
Shipping	Dry ice
Availability Status	Made to order
Handling Notes	Upon receipt, this product must be immediately transferred from dry ice to liquid nitrogen (-150°C to -190°C) and stored in a liquid nitrogen tank. Cell viability is critically dependent on proper handling. We cannot guarantee viability if these instructions are not strictly adhered to.
Product Disclaimer	This product is provided for research only, not suitable for human or animal use. Due to the inherent limitations of infectious agent testing, investigators must exercise extreme caution when handling cells provided by Creative Biolabs, treating all cells as potentially biohazardous.

Target	SLC2A4
Full Name	Solute Carrier Family 2 Member 4
Alternative Name	GLUT4
Location	17p13.1
Gene ID	6517
Summary	A member of the solute carrier 2 family, this gene encodes an insulin-responsive glucose transporter. In muscle and adipose cells, it is retained intracellularly until insulin triggers its relocation to the plasma membrane, enabling glucose uptake. Mutations have been linked to noninsulin-dependent diabetes mellitus.