Recombinant Human F7 Protein, Glycoengineered Mannose-5 Pichia pastoris (CAT#: GLJF-0722-JF286)

Product Overview	Recombinant Human F7 protein (NP_000122.1) is produced in Glycoengineered Mannose-5 Pichia pastoris. This expression system is used for the production of glycoproteins and antibodies with a mannose-5 structure at N-linked sites.
Source	Glycoengineered Mannose-5 Pichia pastoris
Species	Human
Tag	His-tag, FC-tag
Purity	>90%, determined by SDS-PAGE.
Endotoxin Level	Regular batch
Conjugation	None

Target	F7
Full Name	Coagulation factor VII
Gene ID	2155
Uniprot ID	P08709
Accession Number	NP_000122.1
Background	This gene encodes coagulation factor VII which is a vitamin K-dependent factor essential for hemostasis. This factor circulates in the blood in a zymogen form, and is converted to an active form by either factor IXa, factor Xa, factor XIIa, or thrombin by minor proteolysis. Upon activation of the factor VII, a heavy chain containing a catalytic domain and a light chain containing 2 EGF-like domains are generated, and two chains are held together by a disulfide bond. In the presence of factor III and calcium ions, the activated factor then further activates the coagulation cascade by converting factor IX to factor IXa and/or factor X to factor Xa. Defects in this gene can cause coagulopathy. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar proteolytic processing to generate mature polypeptides.
Alternate Names	Coagulation Factor VII; Coagulation Factor VII (Serum Prothrombin Conversion Accelerator); Eptacog Alfa; FVII Coagulation Protein; Proconvertin; EC 3.4.21.21; SPCA; Serum Prothrombin Conversion Accelerator; Factor VII; EC 3.4.21