Recombinant Human F7 Protein, Glycoengineered Human Cell Lines

Recombinant Human F7 protein (NP_000122.1) is produced in Glycoengineered Human Cell Lines. This expression system is used for the production of glycoproteins and antibodies with human post-translational modifications.

Glycoengineered Human Cell Lines

Human

His-tag, FC-tag

>90%, determined by SDS-PAGE.

Regular batch

None

F7

Coagulation factor VII

This gene encodes coagulation factor VII which is a vitamin K-dependent factor essential for hemostasis. This factor circulates in the blood in a zymogen form, and is converted to an active form by either factor IXa, factor Xa, factor XIIa, or thrombin by minor proteolysis. Upon activation of the factor VII, a heavy chain containing a catalytic domain and a light chain containing 2 EGF-like domains are generated, and two chains are held together by a disulfide bond. In the presence of factor III and calcium ions, the activated factor then further activates the coagulation cascade by converting factor IX to factor IXa and/or factor X to factor Xa. Defects in this gene can cause coagulopathy. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar proteolytic processing to generate mature polypeptides.

Coagulation Factor VII; Coagulation Factor VII (Serum Prothrombin Conversion Accelerator); Eptacog Alfa; FVII Coagulation Protein; Proconvertin; EC 3.4.21.21; SPCA; Serum Prothrombin Conversion Accelerator; Factor VII; EC 3.4.21