Cancer Epitope Analysis Services
Creative Biolabs offers specialized assays for cancer epitope analysis, leveraging extensive expertise in B and T cell immune responses. Our services are designed to help you thoroughly characterize the molecular features of cancer antigens—including both MHC Class I and Class II binding, and B cell receptor recognition. This deep, comprehensive characterization provides the essential foundation needed to rationally design and develop next-generation targeted immunotherapies, such as personalized cancer vaccines and adoptive T cell therapies.
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Understanding the Enemy: What Are Cancer Epitopes?
To an immunologist, a cancer cell is a treasure trove of potential neoantigens. The most critical finds are immunogenic epitopes—the precise molecular "red flags" that T cells and B cells are trained to attack.
This hunt is a two-pronged effort:
T-cell epitopes are like internal intelligence. They are short peptides from degraded proteins, displayed on the cell surface by MHC molecules. CD8+ T-cells recognize MHC I on infected cells to kill them, while CD4+ T-cells see MHC II on immune cells to orchestrate the response.
Conversely, B-cell epitopes are the surface markers. They are specific shapes on the intact antigen, either linear sequences or, more commonly, complex 3D structures. When a B cell binds these, it can produce antibodies that precisely target the invader, flagging it for destruction. This dual recognition is the cornerstone of a coordinated immune attack.
Our Comprehensive Suite of Cancer Epitope Analysis Assays
Immune cell types and cell biological activities are used to categorize services. Depending on your subject, you can use a single assay or a combination of assays to analyze cancer epitopes. We offer the following assay services. If you do not see any services that suit your needs, please contact us for a personalized inquiry.
T CELL-BASED ASSAYS
Proliferation Assays
Cytotoxicity Assays
Binding Kinetics Assays
Inflammatory Cytokines Release Assays
Activation, Degranulation, Antibody help Assay
Suppression Assay
Type IV hypersensitivity (DTH) Assay
3D Structure Assay
Disease State, Pathogen burden, Survival Before and After Adoptive Transfer Assay
B CELL-BASED ASSAYS
Qualitative Binding Assays
Quantitative Binding (Dissociation Constant KD, Association Constant KA, Off Rate, On Rate) Assays
Antibody Activity, Cellular Cytotoxicity, Antigen Activation, Neutralization Assay
In Vivo Activity, Hemagglutination Inhibition, Opsonization, Agglutination Assay
3D Structure Assays
Disease State, Tumor Burden, Survival Before and After Adoptive Transfer Assay
We invite you to contact us today to discuss how our service can provide the critical data you need to drive your next breakthrough.
How We Can Assist Your Project
Creative Biolabs' cancer epitope analysis assays provide you with the critical data needed to move your immunotherapy project forward with confidence. We deliver a prioritized list of validated epitopes, a comprehensive project report, and the raw data files required for your internal analysis.
Why Choose Us?
When you choose Creative Biolabs, you're not just getting a service; you're gaining a partner with over two decades of specialized experience in immuno-oncology. Our team of world-class scientists uses state-of-the-art technology and a meticulous approach to ensure the highest quality and most reliable results.
Broad Range of Cancer Antigens Covered
We analyze mutated gene-encoded proteins, cancer germline antigens, infectious virus-related cancer antigens, and overexpressed antigens.
Accurate & Reproducible Data
Utilizing advanced instruments and validated reagents, we provide highly accurate, reproducible, sensitive, and specific data for epitope determination.
Robust Technology Platform
Our cutting-edge techniques and state-of-the-art equipment ensure a robust and reliable platform for your research.
Highly Skilled Team of Experts
A dedicated team of experts leverages their deep knowledge to deliver unparalleled insights and support.
Discover how we can help your project succeed. Request a consultation today to begin the conversation about your specific goals.
FAQs
Q1: How is your epitope prediction approach different from standard bioinformatics tools?
A1: While many tools focus solely on MHC binding affinity, our model integrates both binding prediction and antigen abundance from gene expression data. This multi-faceted approach, validated by published data, provides a more accurate and robust list of potential epitopes.
Q2: What is the benefit of validating predicted epitopes experimentally?
A2: Bioinformatic prediction is a powerful screening tool, but direct experimental identification using techniques like mass spectrometry provides definitive proof that an epitope is actually presented on the tumor cell surface.
Q3: Can you help with low-expressing antigens?
A3: Absolutely. Our integrated approach is designed to handle this challenge. By factoring in antigen abundance, we can better prioritize potential epitopes even from transcripts with lower expression levels, ensuring you don't miss any relevant targets.
Customer Review
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Enhanced Epitope Prediction Accuracy
Using Creative Biolabs' service in our research has significantly improved the accuracy of our T-cell epitope predictions. Their model's inclusion of antigen abundance data provided a level of confidence that standard MHC binding assays simply can't match. - Dr. A*dew
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Direct Experimental Validation
The direct identification of epitopes from our tumor samples via mass spectrometry was a game-changer. It validated our bioinformatic predictions and gave us a clear, preclinically relevant list of targets to pursue for our next-generation T-cell therapy. – Sra*Bne
Related Services
Our cancer epitope analysis assays are often a critical first step in a broader project. We offer several complementary services to support your research from start to finish.
TCR/CAR Expression Analysis
Creative Biolabs provides cost-effective TCR/CAR expression analysis services. With a team of Ph.D. scientists and state-of-the-art instruments, we offer a range of validation assays using methods like WB, ELISA, and FCM to provide reliable data and comprehensive analysis reports.
Learn More →
T Cell-based Multimer/Tetramer Assay
Creative Biolabs offers synthesized peptide-MHC multimer/tetramer for cancer epitope analysis. Inspired by the unique binding between TCR and peptide-MHC, this service helps identify antigen-specific T cells, which respond quickly to antigen infection.
Learn More →
Contact Us
Creative Biolabs is your trusted partner in advancing cancer immunotherapy. Our tailored approach, backed by over two decades of experience, ensures that you receive the highest quality data to accelerate your project.
To learn more about our cancer epitope analysis assays and to discuss your specific research needs, please reach out to our team of experts.
