Pancreatic Cancer related Tumor Profiling Service
Tumor profiling in pancreatic cancer shows great significance in helping identify key molecular alterations, guide targeted therapies, and predict treatment responses and resistance. With our advanced platform of Tumor Profiling to Guide Targeted Cancer Therapy, Creative Biolabs has developed an unparalleled platform for tumor profiling in pancreatic cancer to facilitate your oncology research. To fulfill every need of our consumers, our professional scientists are ready to start working on your project!
Background
Pancreatic cancer is a common worldwide cancer with a high lethal rate. The factors that contribute to its high fatality rate include the high genetic and epigenetic heterogeneity, therapeutic limitations, high metastatic propensity, and metabolic reprogramming of cancer cells. A comprehensive pancreatic tumor profiling could help intervene in tumor development, progression, and drug resistance.
Fig.1 The characteristics of pancreatic cancer.1
Advanced Multi-Tumor Profiling System
Looking to unlock deeper insights into tumor heterogeneity? Creative Biolabs stands at the forefront of cancer research with our sophisticated tumor profiling solutions. Drawing upon cutting-edge platforms, we've successfully characterized diverse tumor populations across 10 major cancer types - from pancreatic cancer to non-small cell lung cancer and colorectal cancer. What sets us apart isn't just our advanced biomarker panels; it's our passionate team of scientists who work hand-in-hand with pharmaceutical companies and research institutions to accelerate drug development. While others might offer standard analytics, we pride ourselves on delivering actionable insights that drive your oncology programs forward. Ready to elevate your cancer research? Let's explore how our tumor profiling expertise can unlock new possibilities for your projects.
| Well-studied Biomarkers | ||||
|---|---|---|---|---|
| Technologies | Genetic | Chromosomal | Transcriptional | Proteomic |
| Pancreatic Cancer | ||||
|
NGS FISH PCR IHC Microarray |
Gene Variations KRAS TP53 SMAD4 CDKN2A RREB1 KDM6A RAC1 ARMET BRAF TGFBR2 ACVR1B MAP3K21 RAS ARMET RNF43 |
Chr 1~22 and Chr X, insertions, deletions, duplications, inversions and translocations |
MicroRNAs, Long noncoding RNAs, DNA methylation |
CA 19-9 |
| Breast Cancer | ||||
|
NGS ISH PCR IHC Microarray |
BRAF TP53 EGFR BRCA1/2 KRAS ERBB2/4 CDH1 MET CDK12 PTEN FGFR1/2/3 HRAS CHEK1/2 PIK3CA ATM |
MET PTEN |
HER2 ER PR |
PD-L1 22C3 Pan-TRK |
| Non-Small Cell Lung Cancer (NSCLC) | ||||
|
NGS FISH PCR IHC Microarray FC IF |
STK11 AKT1 EGFR BRAF KRAS ERBB2/4 TP53 MET FGFR1/2/3 CCND1 PTEN HRAS RB1 PIKЗCA ATM |
ALK MET PTEN RET |
VEGFA |
PD-L1 HER2 Pan-TRK |
| Colorectal Cancer | ||||
|
NGS FISH IHC FC LC-MS |
ALK AKT1 EGFR BRAF KRAS ERBB2/4 TP53 MET FGFR1/2/3 NOTCH1 PTEN ROS1 RB1 PIK3CA ATM |
ALK MET PTEN RET ROS1 |
PD-L1 |
PD-L1 HER2 Pan-TRK |
| Melanoma Cancer | ||||
|
NGS FISH PCR IHC Microarray FC |
AKT1 EGFR BRAF ERBB2/4 FGFR1/2/3 MET PDFFRA NRAS KIT CDK4 |
PTEN | MITF |
PD-L1 Pan-TRK |
| Brain Cancer | ||||
|
NGS ISH PCR IHC Microarray |
EGFR TP53 IDH1 EPHB2 APC MYC MLHI BAP1 SMAD4 COL4A1 ERBB2 HRAS AKT1 CDKN2B EPCAM |
CDKN2A(p16) deletion EGFR amplification MET amplification CDKN2A (p16) deletion |
ALK RAF1 BRAF ROS1 EGFR FGFR1 |
GFAP S100B |
| Ovarian Cancer | ||||
|
NGS FISH PCR IHC Microarray RT-PCR ELISA Whole Transcriptome Sequencing DNA Methylation |
CTNNB1 PRKN TP53 PIKЗCA OPCML AKTI CDH1 ERBB2 RRAS2 PARK2 BRCA1/2 STK11 CDKN2B EPCAM |
hyper- and hypo-methylation: OPCML DCR1 RASSF1A BRCA1 histone modification and miRNAs: Sirtuin-1 TGF |
Cytokines/Chemokines: MFAP2 SEMG2 DLK1 Pro-apoptotic Proteins: NTNG1 CA-125 ILs XCL1 Angiogenic factors: CXCL7 VEGF EGFR ErbB2 |
|
| Endometrial Cancer | ||||
|
NGS FISH PCR IHC Microarray FC IF RT-PCR ELISA |
BRAF PIKЗCA APC BRCA1/2 SMAD4 HRAS TP53 CDH1 EGFR EPCAM KIT PTEN ESR1 MSH2/6 NRAS PDGFRA SMO SMARCA4 ATM FGFR1/2/3 |
MET PTEN |
PD-L1 |
HER2 PDL1 |
| Thyroid Cancer | ||||
|
NGS FISH PCR IHC Microarray |
TP53 KRAS ERBB2/4 ALK ATM BRAF CDKN2A RET PIK3CA SMO CDKN2A PTEN SMAD4 HRAS CTNNB1 |
MET RET |
PD-L1 |
Pan-TRK PD-L1 |
| Head and Neck Cancer | ||||
|
NGS FISH PCR IHC Microarray IF ELISA |
PTEN TP53 PTEN KRAS EGFR CTNNB1 BRAF PIK3CA ERBB2 FGFR1/2/3 CDKN2A NOTCH1 AKT1 RB1 ATM |
MET PTEN RET |
PD-L1 |
Pan-TRK PD-L1 |
Tumor Profiling in Pancreatic Cancer Is Used for
-
Personalized Cancer Treatment
Creative Biolabs provides comprehensive tumor profiling services to guide personalized cancer treatment, utilizing genomic, transcriptomic, and proteomic analyses. These services help identify actionable biomarkers and understand tumor heterogeneity to optimize therapeutic strategies.
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Diagnostic Tool
Our tumor profiling services serve as a powerful diagnostic tool, combining genomic, transcriptomic, and proteomic analyses to enhance cancer diagnosis and treatment planning by identifying key biomarkers and molecular alterations.
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Biomarker Discovery
Creative Biolabs specializes in tumor profiling for biomarker discovery, employing advanced genomic, transcriptomic, and proteomic techniques to identify novel biomarkers, accelerating cancer research, and facilitating the development of targeted therapies.
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Prognostic Assessment
Our tumor profiling services also support prognostic assessments, helping to predict disease outcomes by analyzing key biomarkers and molecular signatures, enabling personalized treatment strategies and informed clinical decision-making.
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Workflow for Pancreatic Tumor Profiling
- Fresh/FFPE tissue or liquid biopsy
- Quality control and preservation
- Sample validation
- Genomic profiling (WES/targeted sequencing)
- RNA sequencing
- Proteomic analysis
- Metabolomic profiling
- Bioinformatics pipeline
- Pathway analysis
- Target identification
- Clinical relevance assessment
- Comprehensive report
- Data visualization
- Therapeutic implications
- Expert consultation
If you have any specific requirements for the whole profiling process, please do not hesitate to get in touch with us and our professional experts can tailor the tumor profiling services according to your needs.
Get Your Tailored Service Now →
Why Choose Us?
Creative Biolabs offers high-quality services to support tumor profiling research. If you are interested in our services, contact us directly, and our team will give you an in-time reply.
Reference
- Wang, Shun, et al. "The molecular biology of pancreatic adenocarcinoma: translational challenges and clinical perspectives." Signal transduction and targeted therapy 6.1 (2021): 249. Distributed under Open Access license CC BY 4.0, without modification.
