GlycoErase™ SLC37A4 Knockout HepG2 Cell Line (CAT#: GLJF-0825-JF715)

Description	GlycoErase™ SLC37A4 knockout HepG2 cell line is a human HepG2 model lacking SLC37A4 expression, which encodes the ER glucose-6-phosphate transporter that shuttles G6P into the ER lumen to sustain glucose homeostasis and contribute to ATP-driven Ca²⁺ sequestration. This knockout model enables investigations into glycogen storage disease mechanisms, ER-glucose flux, and calcium-metabolism coupling in liver cells, supporting metabolic disorder research and therapeutic screening.
Product Type	KO Cell Lines
Species	Human
Cell Morphology	Epithelial-like, adherent
Passage Ratio	1:4~1:6
Cell Line	HepG2
Primary Disease	Hepatoblastoma
Lineage	Liver
Lineage Subtype	Hepatoblastoma

Cell Viability	>90%
Sterility Test	The sterility test indicated an absence of microbial growth.
Identity Test	STR identification
Mycoplasma Test	Negative
Virus Test	Negative for HIV, HBV and HCV.
Genetic Stability Testing	We conduct cell genetic stability studies in full compliance with ICH guidelines. Our expertise enables us to design and execute a comprehensive testing program tailored to your specific needs and regulatory requirements.
Validation	PCR, Sanger Sequencing
Culture Medium	DMEM & FBS & Glutamine
Application	Functional assay
Size	1 M cells/vial*2
Product Format	Frozen
Shipping	Dry ice
Availability Status	Made to order
Handling Notes	Upon receipt, this product must be immediately transferred from dry ice to liquid nitrogen (-150°C to -190°C) and stored in a liquid nitrogen tank. Cell viability is critically dependent on proper handling. We cannot guarantee viability if these instructions are not strictly adhered to.
Product Disclaimer	This product is provided for research only, not suitable for human or animal use. Due to the inherent limitations of infectious agent testing, investigators must exercise extreme caution when handling cells provided by Creative Biolabs, treating all cells as potentially biohazardous.

Target	SLC37A4
Full Name	Solute Carrier Family 37 Member 4
Alternative Name	G6PT; SPX4; CDG2W; G6PT1; G6PT2; G6PT3; GSD1b; GSD1c; GSD1d; TRG19; TRG-19; PRO0685
Location	11q23.3
Gene ID	2542
Summary	This gene regulates glucose-6-phosphate transport into the endoplasmic reticulum lumen to maintain glucose balance and is also involved in ATP-dependent calcium sequestration. Mutations are linked to various glycogen storage diseases.