Longevity Validation Services

We use epistasis analysis to systematically test functional linkages across the network, delivering a precise map that definitively separates true causal longevity drivers from passive bystanders or correlative markers.

Leveraging proprietary AI algorithms and the fokker-planck equation, we model your target's influence on the entire aging Epigenetic Landscape, providing predictive data on therapeutic efficacy before you commit to costly compound screening.

High-resolution, quantitative tracking of core longevity hallmarks, including SASP status, global methylation changes, and mitochondrial function, executed within a single, streamlined workflow for superior data integration.

Implementation of the most advanced genetic tools (CRISPR/shRNA) supported by comprehensive, well-established quality verification procedures for all perturbation steps, ensuring maximum data integrity and reproducibility.

This service provides high-resolution live imaging to validate Longevity GRN dynamics and key oscillatory behaviors directly within individual cells. This approach offers unparalleled temporal and spatial insight into how genetic perturbations affect the aging process.

We utilize the well-characterized yeast replicative aging model to conduct rapid, high-throughput screens. This provides robust, conserved GRN analysis, quickly identifying potential longevity drivers and establishing foundational regulatory principles efficiently.

This comprehensive service employs the C. elegans post-mitotic model for whole-organism GRN studies. The focus is on complex, integrated physiological systems, including neuronal aging and crucial metabolic feedback pathways relevant to longevity mechanisms.

This service offers comprehensive GRN validation in complex mammalian systems, ensuring the highest level of late-stage scientific confidence. We typically perform tissue-specific genetic perturbation to confirm target causality in a physiologically relevant context.

This is a crucial causal validation service utilizing loss-of-function techniques, including shRNA and CRISPR-i. We precisely assess the necessity of your target gene by measuring the resulting GRN and phenotypic shifts upon its specific suppression.

We perform causal validation using gain-of-function perturbation techniques to test sufficiency. This measures the ability of your target to force a youthful phenotype or restore network stability, providing definitive evidence of its regulatory power.

This service focuses on disrupting the protein function of a longevity target using tools like dominant negative forms. We validate the GRN without altering transcript levels, offering clear mechanistic insight into its post-translational regulatory role.

This validation is centered on perturbing major upstream regulators, such as mTOR and AMPK. We confirm the causal flow of regulatory signals to downstream GRN targets, mapping the command structure of the longevity network hierarchy.

This service is dedicated to GRN mapping of metabolic feedback loops. We analyze how network targets and regulatory dynamics respond to and control dietary and nutrient signals, which are critical drivers of the aging process.

We focus on validating GRN targets centrally involved in mitochondrial quality control and energy metabolism. This service quantifies the regulatory link between your gene of interest and core mechanisms of bioenergetic maintenance and stress response.

This service involves detailed GRN studies focused on regulatory networks governing protein folding, aggregation, and degradation pathways. We analyze network stability under proteotoxic stress to validate targets that maintain cellular cleanliness.

We provide validation of targets involved in DNA repair mechanisms and chromatin maintenance feedback loops. This service confirms the causal role of your gene in preventing age-related deterioration of the genome's structural integrity.

This involves the validation of engineered genetic circuits designed to impose stable, pro-longevity dynamics on the native GRN. We test the efficacy of these synthetic oscillators in restoring rhythmic and youthful cellular function.