Recombinant ICOSLG Protein (Asp 19-Ser 258) [Fc] (VAng-1594Lsx)

Human ICOSLG (B7-H2), Fc tag, is expressed in HEK 293 cells. (Uniprot ID: O75144-1)

Datasheet

Specifications

Source

HEK293 Cells.

Target

ICOSLG

Type

Tumor Antigens

Applications

SDS-PAGE; WB; ELISA.

Formulation

Tris with Glycine, Arginine and NaCl, pH 7.5.

Purity

> 95% pure by SDS-PAGE.

Storage

Store at -20°C to -80°C.

Antigen Information

Introduction

ICOSLG is a protein that in humans is encoded by ICOSLG gene. ICOSLG promotes an entangled mode of follicular T-helper/B-cell interactions, characterized by brief but extensive surface engagement, productive T-cell calcium spikes, and B-cell acquisition of CD40 signals. Reiterated entanglement promotes outer zone colocalization of outcompeting germinal center B cells together with follicular T-helper cells, affording the former increased access to T-cell help. ICOSLG on germinal center B cells is upregulated by CD40 signals.

Alternative Names

ICOSLG, B7-H2, B7H2, B7RP-1, B7RP1, CD275, GL50, ICOS-L, ICOSL, LICOS, ICOS ligand