Recombinant ICOSLG Protein (Asp 19-Ser 258) [His] (VAng-1595Lsx)
Human ICOSLG (B7-H2), His tag, is expressed in HEK 293 cells. (Uniprot ID: NP_056074)
Datasheet
Specifications
Source
HEK293 Cells.
Target
ICOSLG
Type
Tumor Antigens
Applications
SDS-PAGE; WB; ELISA.
Formulation
PBS, pH 7.4.
Purity
> 95% pure by SDS-PAGE.
Storage
Store at -20°C to -80°C.
Antigen Information
Introduction
ICOSLG is a protein that in humans is encoded by ICOSLG gene. ICOSLG promotes an entangled mode of follicular T-helper/B-cell interactions, characterized by brief but extensive surface engagement, productive T-cell calcium spikes, and B-cell acquisition of CD40 signals. Reiterated entanglement promotes outer zone colocalization of outcompeting germinal center B cells together with follicular T-helper cells, affording the former increased access to T-cell help. ICOSLG on germinal center B cells is upregulated by CD40 signals.
Alternative Names
ICOSLG, B7-H2, B7H2, B7RP-1, B7RP1, CD275, GL50, ICOS-L, ICOSL, LICOS, ICOS ligand
Related Product
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