Recombinant ANGPT2 Protein (Met1-Phe496) [His] (VAng-Cr3805)
Recombinant ANGPT2 Protein (Met1-Phe496) fused with a His tag at C-terminus was expressed in Mammalian cells, with a molecular weight of 60-70 kDa. (Uniprot ID: O15123)
Applications
SDS-PAGE; WB; ELISA.
Formulation
Protein lyophilized in sterile PBS/Protein store in sterile PBS.
Purity
> 90% pure by SDS-PAGE.
Storage
Store at -20 °C to -80 °C.
Introduction
ANGPT2 is a protein that in humans is encoded by ANGPT2 gene. Angiopoietin 2 (ANG-2) is an angiogenic peptide released by endothelial cells, which plays an essential role in modulating angiogenesis and vascular homeostasis. It binds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating ANGPT1 signaling. It can induce tyrosine phosphorylation of TEK/TIE2 in the absence of ANGPT1. In the absence of angiogenic inducers, such as VEGF, ANGPT2-mediated loosening of cell-matrix contacts may induce endothelial cell apoptosis with consequent vascular regression. In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal.
Alternative Names
AGPT2; ANG2; angiopoietin 2
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