Recombinant CD40L Protein (Glu108-Leu261) [His] (VAng-Cr3831)
Recombinant CD40L Protein (Glu108-Leu261) fused with a His tag at C-terminus was expressed in Mammalian cells, with a molecular weight of 18 kDa. (Uniprot ID: P29965)
Datasheet
Specifications
Source
Mammalian cells
Target
CD40L
Type
Tumor Antigens
Applications
SDS-PAGE; WB; ELISA.
Formulation
Protein lyophilized in sterile PBS/Protein store in sterile PBS.
Purity
> 90% pure by SDS-PAGE.
Storage
Store at -20 °C to -80 °C.
Antigen Information
Introduction
CD40L is a protein that is primarily expressed on activated T cells and is a member of the TNF superfamily of molecules. It binds to CD40 (protein) on antigen-presenting cells (APC), which leads to many effects depending on the target cell type. In total CD40L has three binding partners. CD154 acts as a costimulatory molecule and is particularly important on a subset of T cells called T follicular helper cells. It promotes B cell maturation and function by engaging CD40 on the B cell surface and therefore facilitating cell-cell communication. A defect in this gene results in an inability to undergo immunoglobulin class switching and is associated with hyper IgM syndrome.
Alternative Names
CD40LG; CD154; CD40L; HIGM1; IGM; IMD3; T-BAM; TNFSF5; TRAP; gp39; hCD40L; CD40 ligand
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