Recombinant GPC3 Protein (Met1-His559) [His] (VAng-Cr3802)

Recombinant GPC3 Protein (Met1-His559) fused with a His tag at C-terminus was expressed in Mammalian cells, with a molecular weight of 40-66 kDa. (Uniprot ID: P51654)

Datasheet

Specifications

Source

Mammalian cells

Target

GPC3

Type

Tumor Antigens

Applications

SDS-PAGE; WB; ELISA.

Formulation

Protein lyophilized in sterile PBS/Protein store in sterile PBS.

Purity

> 90% pure by SDS-PAGE.

Storage

Store at -20 °C to -80 °C.

Antigen Information

Introduction

GPC3 is a protein that in humans is encoded by GPC3 gene. The protein core of GPC3 consists of two subunits, where the N-terminal subunit has a size of -40 kDa and the C-terminal subunit is -30 kDa. Six glypicans (GPC1-6) have been identified in mammals. Cell surface heparan sulfate proteoglycans are composed of a membrane-associated protein core substituted with a variable number of heparan sulfate chains. Members of the glypican-related integral membrane proteoglycan family (GRIPS) contain a core protein anchored to the cytoplasmic membrane via a glycosyl phosphatidylinositol linkage. These proteins may play a role in the control of cell division and growth regulation. GPC3 interacts with both Wnt and frizzled (FZD) to form a complex and triggers downstream signaling.

Alternative Names

DGSX; GTR2-2; MXR7; OCI-5; SDYS; SGB; SGBS; SGBS1; Glypican 3