Recombinant Human A1AT Protein (aa 1-121) [GST] (VAng-2988Lsx)
Recombinant Human Alpha 1 Antitrypsin Antigen is expressed in E. coli. (Uniprot ID: O43768)
Datasheet
Specifications
Source
E. coli
Target
Alpha 1 Antitrypsin
Type
Tumor Antigens
Applications
SDS-PAGE; WB; ELISA.
Formulation
20 mM Tris-HCl based buffer, pH 8.0
Purity
> 95% pure by SDS-PAGE.
Storage
Store at ≤-20°C.
Antigen Information
Introduction
A1AT is a protein belonging to the serpin superfamily. It is encoded in humans by A1AT gene. As a type of enzyme inhibitor, it protects tissues from enzymes of inflammatory cells, especially neutrophil elastase, and has a reference range in blood of 0.9–2.3 g/L. When the blood contains inadequate amounts of A1AT or functionally defective A1AT (such as in alpha-1 antitrypsin deficiency), neutrophil elastase is excessively free to break down elastin, degrading the elasticity of the lungs, which results in respiratory complications, such as chronic obstructive pulmonary disease, in adults. Normally, A1AT leaves its site of origin, the liver, and joins the systemic circulation; defective A1AT can fail to do so, building up in the liver, which results in cirrhosis in either adults or children.
Alternative Names
A1AT; A1A; AAT; PI; PI1; PRO2275
Related Product
All of our products can only be used for research purposes. These vaccine ingredients CANNOT be used directly on humans or animals.
