Recombinant Human ANGPT2 Protein (aa 19-496, 19-483) (Yeast) [His] (VAng-3078Lsx)
Recombinant Human Angiopoietin-2 protein, expressed in Yeast. (Uniprot ID: O15123)
Datasheet
Specifications
Source
Yeast
Target
ANGPT2
Type
Tumor Antigens
Applications
SDS-PAGE; WB; ELISA.
Formulation
20 mM Tris-HCl based buffer, pH 8.0.
Purity
> 95% pure by SDS-PAGE.
Storage
Store at -20°C to -80°C.
Antigen Information
Introduction
ANGPT2 is a protein that in humans is encoded by ANGPT2 gene. Angiopoietin 2 (ANG-2) is an angiogenic peptide released by endothelial cells, which plays an essential role in modulating angiogenesis and vascular homeostasis. It binds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating ANGPT1 signaling. It can induce tyrosine phosphorylation of TEK/TIE2 in the absence of ANGPT1. In the absence of angiogenic inducers, such as VEGF, ANGPT2-mediated loosening of cell-matrix contacts may induce endothelial cell apoptosis with consequent vascular regression. In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal.
Alternative Names
ANGPT2, AGPT2, ANG2, Angiopoietin-2
Related Product
All of our products can only be used for research purposes. These vaccine ingredients CANNOT be used directly on humans or animals.
