Recombinant ITGA2B Protein (Met1-Arg993) [His] (VAng-Cr3750)
Recombinant ITGA2B Protein (Met1-Arg993) fused with a His tag at C-terminus was expressed in Mammalian cells, with a molecular weight of 140-150 kDa. (Uniprot ID: P08514)
Datasheet
Specifications
Source
Mammalian cells
Target
ITGA2B
Type
Tumor Antigens
Applications
SDS-PAGE; WB; ELISA.
Formulation
Protein lyophilized in sterile PBS/Protein store in sterile PBS.
Purity
> 90% pure by SDS-PAGE.
Storage
Store at -20 °C to -80 °C.
Antigen Information
Introduction
ITGA2B a protein that in humans is encoded by ITGA2B gene. ITGA2B, also known as CD41, encodes integrin alpha chain 2b. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Alpha chain 2b undergoes post-translational cleavage to yield disulfide-linked light and heavy chains that join with beta 3 to form a fibrinogen receptor expressed in platelets that plays a crucial role in coagulation. Mutations that interfere with this role result in thrombasthenia. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling. It is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. It recognizes the sequence R-G-D in a wide array of ligands. It recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain.
Alternative Names
ITGA2B; GP2B; ITGAB
All of our products can only be used for research purposes. These vaccine ingredients CANNOT be used directly on humans or animals.
