Recombinant ITGA4 Protein (Met1-Thr977) [His] (VAng-Cr3762)
Recombinant ITGA4 Protein (Met1-Thr977) fused with a His tag at C-terminus was expressed in Mammalian cells, with a molecular weight of 150-170 kDa. (Uniprot ID: P13612)
Datasheet
Specifications
Source
Mammalian cells
Target
ITGA4
Type
Tumor Antigens
Applications
SDS-PAGE; WB; ELISA.
Formulation
Protein lyophilized in sterile PBS/Protein store in sterile PBS.
Purity
> 90% pure by SDS-PAGE.
Storage
Store at -20 °C to -80 °C.
Antigen Information
Introduction
ITGA4 belongs to the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. ITGA4 gene encodes an alpha 4 chain. Unlike other integrin alpha chains, alpha 4 neither contains an I-domain, nor undergoes disulfide-linked cleavage. Alpha 4 chain associates with either beta 1 chain or beta 7 chain. Integrins alpha-4/beta-1 (VLA-4) and alpha-4/beta-7 are receptors for fibronectin. They recognize one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. They are also receptors for VCAM1. Integrin alpha-4/beta-1 recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-4/beta-7 is also a receptor for MADCAM1. It recognizes the sequence L-D-T in MADCAM1.
Alternative Names
ITGA4
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