Recombinant Mouse ANGPT2 Protein (aa 19-496) (E. coli) (VAng-3072Lsx)

ANGPT2

Tumor Antigens

SDS-PAGE; WB; ELISA.

PBS, pH 7.4.

> 95% pure by SDS-PAGE.

Store at -20°C to -80°C.

ANGPT2 is a protein that in humans is encoded by ANGPT2 gene. Angiopoietin 2 (ANG-2) is an angiogenic peptide released by endothelial cells, which plays an essential role in modulating angiogenesis and vascular homeostasis. It binds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating ANGPT1 signaling. It can induce tyrosine phosphorylation of TEK/TIE2 in the absence of ANGPT1. In the absence of angiogenic inducers, such as VEGF, ANGPT2-mediated loosening of cell-matrix contacts may induce endothelial cell apoptosis with consequent vascular regression. In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal.

ANGPT2, AGPT2, ANG2, Angiopoietin-2