3'3'-cGAMP (VAdv-Ly0020)

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VAdv-Ly0020

3'3'-cGAMP, (cyclic [G(3', 5')pA(3', 5')p]), a STING agonist vaccine adjuvant.

Datasheet

Specifications

Type

PRRs Agonist

Formula

C₂₀H₂₂N₁₀O₁₃P₂▪2Na

Molecular Weight

718.38

Specificity

Th1/Th2 response

Product Form

White solid

Percentage

≥ 95% by LC/MS

Endotoxin

Lower than 5 EU/mg.

Storage

Store at -20°C.

Shelf Life

1 year.

Adjuvant Information

Introduction

3'3'-cGAMP, cyclic [G(3', 5')pA(3', 5')p], is a cyclic dinucleotide produced by bacteria in which it serves as a second messenger and plays a role in chemotaxis and colonization. 3'3'-cGAMP could bind STING and subsequently induce TBK1-IRF3 (TANK-binding kinase 1-IFN regulatory transcription factor 3)-dependent production of IFN-β.