Programmable Self-assembly DNA Nanorobot for Drug Delivery

The most important thing for a drug to successfully exert its effect is to enter the target organs, target tissues, and target cells of the human body. The human body has multiple barrier systems to prevent the invasion of foreign substances. Therefore, it is an important part of drug development to use the physiological structure of the human body and the physical and chemical properties of drugs to develop an appropriate drug delivery system. To this end, Creative Biolabs has developed a programmable self-assembly DNA Nanorobot to solve this problem.

DNA - A Promising Nanocarrier Material

The unique physical and chemical properties of DNA molecules make it a basic self-assembly element for building molecular machine-like nanostructures. DNA nanostructures have shape designability, precise addressability, structural dynamic response, and good biocompatibility, so they can be used as a good drug delivery carrier material. Moreover, by constructing a DNA nanocarrier by addressably loading specific functional elements, the drug can be delivered to diseased tissues and cells in a targeted manner, the drug can be released responsively, the cell uptake rate of the drug can be increased, and its toxic and side effects can also be reduced. By utilizing the excellent self-assembly performance of NDA materials, DNA nanorobots can be constructed to achieve the purpose of exerting specific functions on the nanoscale. For example, DNA nanomachines can automatically walk on two-dimensional surfaces and can sort specific molecules or transfer specific molecules to other DNA machines, while barrel DNA nanomachines can encapsulate goods inside their cavities to deliver drugs in a targeted manner and initiate responsive changes in specific cellular pathways.

Creative Biolabs’ Solution for Drug Delivery - Programmable Self-assembly DNA Nanorobot

DNA nanotechnology was pioneered by Seeman in the 1980s. Rothemund established the DNA origami technology in 2006. In 2012, Yin developed single-stranded brick (SST) technology. By 2017, the preparation of large-size, large-scale DNA nanostructures has also become possible. Scientists from Creative Biolabs not only quickly absorbed the above technologies but skillfully applied these technologies to design and develop programmable self-assembly DNA nanorobots as efficient, low-toxic, targeted, and versatile drug delivery vehicles. Programmable self-assembly DNA nanorobot can be used to deliver small molecule drugs, oligonucleotide drugs and protein drugs.

Programmable self-assembly DNA nanorobot utilizes two unique technologies. One of them is to pre-design the DNA into a specific shape basing on the principle of DNA base pairing, and use short, synthetic DNA strands to self-assemble like Lego® bricks. Another technique is DNA origami. It is practiced under the principle of programmable self-assembly, DNA strands can form tightly cross-linked double helixes of a specific shape. Among them, a long single strand of DNA is used as a "scaffold", and numerous short synthetic DNA strands specially designed by computer software are combined with long-stranded DNA by base pairing of A to T and C to G, and finally these DNA strands are formed into lattice. In this way, DNA origami can be used to create three-dimensional structures and serve as a drug delivery vehicle. Compared with liposomes, polymer carriers, etc., programmable self-assembly DNA nanorobot can be pre-designed in size and shape, has addressable positioning function, is programmable controllable, and has good biocompatibility. Therefore, it is a new type of carrier with great advantages and has a very broad application prospect in delivering various drugs.

Creative Biolabs is the world's leading expert in drug development, and we have unique strengths and experience, especially in the design and development of drug delivery systems. A programmable self-assembly DNA nanorobot developed by taking advantages of the structural and functional properties of DNA will be a promising novel drug delivery system.

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