Recombinant ICOSL Protein (Met1-Ser258) [His] (VAng-Cr3845)
Recombinant ICOSL Protein (Met1-Ser258) fused with a His tag at C-terminus was expressed in Mammalian cells, with a molecular weight of 45 kDa. (Uniprot ID: O75144)
Datasheet
Specifications
Source
Mammalian cells
Target
ICOSL
Type
Tumor Antigens
Applications
SDS-PAGE; WB; ELISA.
Formulation
Protein lyophilized in sterile PBS/Protein store in sterile PBS.
Purity
> 90% pure by SDS-PAGE.
Storage
Store at -20 °C to -80 °C.
Antigen Information
Introduction
ICOSL is a protein that in humans is encoded by ICOSL gene. ICOSLG promotes an 'entangled' mode of follicular T-helper/B-cell interactions, characterized by brief but extensive surface engagement, productive T-cell calcium spikes, and B-cell acquisition of CD40 signals. Reiterated entanglement promotes outer zone colocalization of outcompeting germinal center B cells together with follicular T-helper cells, affording the former increased access to T-cell help. ICOSLG on germinal center B cells is upregulated by CD40 signals.
Alternative Names
B7H2; B7RP1; ICOSLG; KIAA0653
All of our products can only be used for research purposes. These vaccine ingredients CANNOT be used directly on humans or animals.
