Recombinant IL4R Protein (Met1-His232) [His] (VAng-Cr3789)

Recombinant IL4R Protein (Met1-His232) fused with a His tag at C-terminus was expressed in Mammalian cells, with a molecular weight of 43-48 kDa. (Uniprot ID: P24394)

Datasheet

Specifications

Source

Mammalian cells

Target

IL4R

Type

Tumor Antigens

Applications

SDS-PAGE; WB; ELISA.

Formulation

Protein lyophilized in sterile PBS/Protein store in sterile PBS.

Purity

> 90% pure by SDS-PAGE.

Storage

Store at -20 °C to -80 °C.

Antigen Information

Introduction

IL4R is a type I cytokine receptor. IL4R encodes the alpha chain of the interleukin-4 receptor, a type I transmembrane protein that can bind interleukin 4 and interleukin 13 to regulate IgE antibody production in B cells. Among T cells, the encoded protein also can bind interleukin 4 to promote differentiation of Th2 cells. A soluble form of the encoded protein can be produced by an alternate splice variant or by proteolysis of the membrane-bound protein, and this soluble form can inhibit IL4-mediated cell proliferation and IL5 upregulation by T-cells. Allelic variations in this gene have been associated with atopy, a condition that can manifest itself as allergic rhinitis, sinusitis, asthma, or eczema.

Alternative Names

CD124; IL-4RA; IL4RA; Interleukin-4 receptor; interleukin 4 receptor