Recombinant PDCD1LG2 Protein (Met1-Pro219) [His] (VAng-Cr3808)
Recombinant PDCD1LG2 Protein (Met1-Pro219) fused with a His tag at C-terminus was expressed in Mammalian cells, with a molecular weight of 40-45 kDa. (Uniprot ID: Q9BQ51)
Datasheet
Specifications
Source
Mammalian cells
Target
PDCD1LG2
Type
Tumor Antigens
Applications
SDS-PAGE; WB; ELISA.
Formulation
Protein lyophilized in sterile PBS/Protein store in sterile PBS.
Purity
> 90% pure by SDS-PAGE.
Storage
Store at -20 °C to -80 °C.
Antigen Information
Introduction
PDCD1LG2 is a protein that in humans is encoded by PDCD1LG2 gene. PDCD1LG2 expression is inversely associated with Crohn's-like lymphoid reaction to colorectal cancer. It plays a possible role of PDCD1LG2-expressing tumor cells in inhibiting the development of tertiary lymphoid tissues during colorectal carcinogenesis. It is involved in the costimulatory signal, essential for T-cell proliferation and IFNG production in a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation by blocking cell cycle progression and cytokine production.
Alternative Names
B7DC; Btdc; CD273; PD-L2; PDCD1L2; PDL2; bA574F11.2; programmed cell death 1 ligand 2
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