Recombinant TIGIT Protein (Met1-Pro141) [His] (VAng-Cr3848)
Recombinant TIGIT Protein (Met1-Pro141) fused with a His tag at C-terminus was expressed in Mammalian cells, with a molecular weight of 13.99 kDa. (Uniprot ID: Q495A1)
Datasheet
Specifications
Source
Mammalian cells
Target
TIGIT
Type
Tumor Antigens
Applications
SDS-PAGE; WB; ELISA.
Formulation
Protein lyophilized in sterile PBS/Protein store in sterile PBS.
Purity
> 90% pure by SDS-PAGE.
Storage
Store at -20 °C to -80 °C.
Antigen Information
Introduction
TIGIT is an immune receptor present on some T cells and Natural Killer Cells (NK). It is also identified as WUCAM and Vstm3. TIGIT could bind to CD155 (PVR) on dendritic cells (DCs), macrophages, with high affinity, and also to CD112(PVRL2) with lower affinity. TIGIT-Fc fusion protein could interact with PVR on dendritic cells and increase its IL-10 secretion level/decrease its IL-12 secretion level under LPS stimulation, and also inhibit T cell activation. TIGIT's inhibition of NK cytotoxicity can be blocked by antibodies against its interaction with PVR and the activity is directed through its ITIM domain.
Alternative Names
T cell immunoreceptor with Ig and ITIM domains
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