ERBB2
ERBB2 is a protein that in humans is encoded by ERBB2 gene. It has been shown to play an important role in the development and progression of certain aggressive types of breast cancer. Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization.| CAT | Product Name | Source | Product Overview | Target | Type | Datasheet | Size | Price |
|---|---|---|---|---|---|---|---|---|
| VAng-Cr3755 | Recombinant ERBB2 Protein (Met1-Thr652) [His] | Mammalian cells | Recombinant ERBB2 Protein (Met1-Thr652) fused with a His tag at C-terminus was expressed in Mammalian cells, with a molecular weight of 100-110 kDa. (Uniprot ID: P04626) | ERBB2 | Tumor Antigens |  |
100 µg | Inquiry |
| VAng-Cr3982 | Recombinant Rat ERBB2 Protein (aa 4-656) [Fc] | Rat | Recombinant Rat ERBB2 Protein (Met4-Thr656) fused with a Fc tag at C-terminus was expressed in HEK293 Cells, with a molecular weight of 97 kDa. (Accession ID: AAH61863.1) | ERBB2 | Tumor Antigens | |
100 µg | Inquiry |
| VAng-Cr3983 | Recombinant Human ERBB2 Protein (aa 1-652) [His&AVI] (Biotinylated) | HEK293 Cells | Recombinant Human ERBB2 Protein (Met1-Thr652) fused with a AVI tag at C-terminus was expressed in HEK293 Cells, with a molecular weight of 72.6 kDa. (Accession ID: NP_004439.2) The protein was biotinylated by the Biotin-Protein ligase (BirA enzyme) in vivo. | ERBB2 | Tumor Antigens | |
20 µg | Inquiry |
| VAng-Cr3984 | Recombinant Mouse ERBB2 Protein (aa 1-653) [Fc] | Mouse | Recombinant Mouse ERBB2 Protein (Met 1-Thr 653) fused with a Fc tag at C-terminus was expressed in HEK293 Cells, with a molecular weight of 96.7 kDa. (Accession ID: P70424) | ERBB2 | Tumor Antigens | |
100 µg | Inquiry |
| VAng-Cr3985 | Recombinant Rhesus ERBB2 Protein (aa 1-652) [Fc] | Rhesus | Recombinant Rhesus ERBB2 Protein (Met 1-Thr 652) fused with a Fc tag at C-terminus was expressed in HEK293 Cells, with a molecular weight of 96.3 kDa. (Accession ID: XP_001090430.1) | ERBB2 | Tumor Antigens | |
100 µg | Inquiry |
| VAng-Cr3986 | Recombinant Human ERBB2 Protein (aa 676-1255) [GST] | Human | Recombinant Human ERBB2 Protein (Lys 676-Val 1255) fused with a GST tag at N-terminus was expressed in Baculovirus-Insect Cells, with a molecular weight of 92 kDa. (Accession ID: NP_004439.2) | ERBB2 | Tumor Antigens | |
50 µg | Inquiry |
| VAng-Cr3987 | Recombinant Human ERBB2 Protein (aa 1-652) [Fc] | Human | Recombinant Human ERBB2 Protein (Met 1-Thr 652) fused with a Fc tag at C-terminus was expressed in HEK293 Cells, with a molecular weight of 96.1 kDa. (Accession ID: NP_004439.2) | ERBB2 | Tumor Antigens | |
100 µg | Inquiry |
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