c-di-GMP Sodium Salt (VAdv-Ly0023)
| CAT | Size | Price | Quantity | |
|---|---|---|---|---|
| VAdv-Ly0023 |
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c-di-GMP sodium salt, a STING agonist vaccine adjuvant.
Datasheet
Specifications
Type
PRRs Agonist
Formula
C20H22N10O14P2▪2Na
Molecular Weight
734.38
Specificity
Th1/Th2 response
Product Form
White solid
Percentage
≥ 95% by LC/MS
Endotoxin
Lower than 5 EU/mg.
Storage
Store at -20°C.
Shelf Life
1 year.
Adjuvant Information
Introduction
Cyclic di-GMP (c-di-GMP) serves as an intracellular signaling molecule synthesized by bacteria. Recent studies have shown that administering c-di-GMP can elicit robust immune responses both in laboratory settings and within living organisms. This cyclic dinucleotide (CDN) has been found to stimulate the production of cytokines, including type I interferons, via activation of the STING/TBK1/IRF3 pathway. As an adjuvant, it facilitates the recruitment of monocytes and granulocytes and promotes the maturation of dendritic cells. In bacterial systems, c-di-GMP functions prominently as an intracellular messenger, influencing various cellular processes.
Related Product
All of our products can only be used for research purposes. These vaccine ingredients CANNOT be used directly on humans or animals.
