Recombinant CD22 Protein (Met1-Arg687) [His] (VAng-Cr3795)
Recombinant CD22 Protein (Met1-Arg687) fused with a His tag at C-terminus was expressed in Mammalian cells, with a molecular weight of 77 kDa. (Uniprot ID: P20273)
Applications
SDS-PAGE; WB; ELISA.
Formulation
Protein lyophilized in sterile PBS/Protein store in sterile PBS.
Purity
> 90% pure by SDS-PAGE.
Storage
Store at -20 °C to -80 °C.
Introduction
CD22 is found on the surface of mature B cells and to a lesser extent on some immature B cells. Generally speaking, CD22 is a regulatory molecule that prevents the overactivation of the immune system and the development of autoimmune diseases. CD22 is a sugar binding transmembrane protein, which specifically binds sialic acid with an immunoglobulin (Ig) domain located at its N-terminus. The presence of Ig domains makes CD22 a member of the immunoglobulin superfamily. CD22 functions as an inhibitory receptor for B cell receptor (BCR) signaling. It is also involved in the B cell trafficking to Peyer's patches in mice.
Alternative Names
SIGLEC-2; SIGLEC2; CD22 molecule
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