Biotinylated Human CD27 Protein (Thr 21-Ile 192) [Fc] (VAng-1228Lsx)
Biotinylated Human CD27, human IgG1 Fc Tag, is expressed in HEK 293 cells. (Uniprot ID: NP_001233)
Datasheet
Specifications
Source
HEK293 Cells.
Target
CD27
Type
Tumor Antigens
Applications
SDS-PAGE; WB; ELISA.
Formulation
50 mM Tris, 100 mM Glycine, pH 7.5.
Purity
> 95% pure by SDS-PAGE.
Storage
Store at -20°C to -80°C.
Antigen Information
Introduction
CD27 is a member of the tumor necrosis factor receptor superfamily. It is currently of interest to immunologists as a co-stimulatory immune checkpoint molecule. The protein encoded by CD27 gene is a member of the TNF-receptor superfamily. This receptor is required for generation and long-term maintenance of T cell immunity. It binds to ligand CD70, and plays a key role in regulating B-cell activation and immunoglobulin synthesis. This receptor transduces signals that lead to the activation of NF-kapper B and MAPK8/JNK. Adaptor proteins TRAF2 and TRAF5 have been shown to mediate the signaling process of this receptor.
Alternative Names
CD27, TNFRSF7, S152, T14, Tp55
Related Product
All of our products can only be used for research purposes. These vaccine ingredients CANNOT be used directly on humans or animals.
