Vaccines for Canine Distemper Virus
Canine distemper virus is a very effective prophylactic disease that causes a large number of canine deaths each year, leading to significant economic losses. Therefore, in addition to good surveillance programs, the most important thing is to develop and produce efficient vaccines to control the disease.
Canine Distemper Virus
Canine distemper (CD) is a highly contagious and fatal disease that can cause severe acute systemic infections characterized by fever, cough, vomiting, diarrhea, and nervous system manifestations. The pathogen causing the disease is canine distemper virus (CDV), which is a negative-sense single-stranded RNA virus belonging to the genus Morbillivirus in the family Paramyxoviridae. The CDV genome encodes six structural proteins, of which hemagglutinin (H) and fusion (F) glycoproteins are protective antigens that induce humoral immunity. Infected species of canine distemper virus include non-human primates, foxes, raccoons, giant pandas, captive Siberian tigers, and red pandas.
Vaccines for Canine Distemper Virus
- Live Attenuated Vaccines
The use of live attenuated CDV vaccines is associated with the development of clinical diseases in exotic carnivores, such as red pandas (Ailurus fulgens), black-footed ferrets (Mustela nigripes), South American bush dogs (Speothos venaticus), and kinkajous (Potos flavus). The live, attenuated CDV vaccine Nobivac has the potential to be used in carnivores because it is attenuated by VERO cells and has a lower virulence reversal potential. We provide specific detection methods to distinguish between wild-type CDV strains and vaccine strains and to develop CDV attenuated vaccines with low virulence and high efficiency.
- Recombinant Vector Vaccine
The canarypox virus-CDV combination vaccine expressing canine distemper virus fusion and hemagglutinin glycoproteins is a safe product that triggers CDV seroconversion without interfering with other vaccine components and protects vaccinated pups from vicious CDV attacks. Recombinant RV expressing the H protein of CDV stimulates high levels of adaptive immune response (VNA) and protects all dogs from lethal CDV challenge. Therefore, the recombinant virus vector producing CDV hemagglutinin can serve as a potential vaccine against canine distemper.
Features
- High safety and high efficiency
- Low virulence
- Low side reaction
Creative Biolabs is a world leader in the field of vaccine development and has focused on the vaccines against a variety of viruses for years. With our extensive experience and advanced platform, we are therefore confident in offering the best development services for canine distemper virus vaccines. If you are interested in our services, please feel free to contact us for more details.
All of our products can only be used for research purposes. These vaccine ingredients CANNOT be used directly on humans or animals.
