Monophosphoryl Lipid A (Synthetic) (VAdv-Ly0012)
Synthetic Monophosphoryl Lipid A, pure compound, a TLR4-based vaccine adjuvant.
Product Form
White powder
Introduction
Synthetic Monophosphoryl Lipid A from E. coli (MPLA) is a pure compound produced by chemical synthesis that displays greatly reduced toxicity while maintaining most of the immunostimulatory activity of lipopolysaccharide. MPLA contains 6 fatty acyl groups, while MPLA purified from bacteria contains a mixture of 5, 6,and 7 acyl lipid A. MPLA is a potent stimulator of T cell and antibody responses. MPLA activates TLR4 but does not activate TLR2 reflecting its high purity. It has been used extensively in clinical trials as a component in prophylactic and therapeutic vaccines targeting infectious disease, cancer and allergies.
All of our products can only be used for research purposes. These vaccine ingredients CANNOT be used directly on humans or animals.