Recombinant Rat ERBB3 Protein (aa 1-641) [Fc] (VAng-Cr3991)

Recombinant Rat ERBB3 Protein (Met1-His641) fused with a Fc tag at C-terminus was expressed in HEK293 Cells, with a molecular weight of 95.5 kDa. (Accession ID: Q62799)

Datasheet

Specifications

Source

Rat

Target

ERBB3

Type

Tumor Antigens

Applications

ELISA.

Formulation

Lyophilized from sterile PBS, pH 7.4.

Purity

> 80% pure by SDS-PAGE.

Storage

Store at -20°C to -80°C.

Antigen Information

Introduction

ERBB3 is a member of the epidermal growth factor receptor (EGFR/ERBB) family of receptor tyrosine kinases. The kinase-impaired ERBB3 is known to form active heterodimers with other members of the ErbB family, most notably the ligand binding-impaired ErbB2. It is expressed in skin, bone, muscle, nervous system, heart, lungs, and intestinal epithelium. It consists of an extracellular domain, a transmembrane domain, and an intracellular domain. The extracellular domain contains four subdomains (I-IV). Subdomains I and III are leucine-rich and are primarily involved in ligand binding. Subdomains II and IV are cysteine-rich and most likely contribute to protein conformation and stability through the formation of disulfide bonds.

Alternative Names

ErbB-3; HER3; LCCS2; MDA-BF-1