Recombinant ERBB3 Protein (Met1-Thr643) [His] (VAng-Cr3796)

Recombinant ERBB3 Protein (Met1-Thr643) fused with a His tag at C-terminus was expressed in Mammalian cells, with a molecular weight of 100-110 kDa. (Uniprot ID: P21860)

Datasheet

Specifications

Source

Mammalian cells

Target

ERBB3

Type

Tumor Antigens

Applications

SDS-PAGE; WB; ELISA.

Formulation

Protein lyophilized in sterile PBS/Protein store in sterile PBS.

Purity

> 90% pure by SDS-PAGE.

Storage

Store at -20 °C to -80 °C.

Antigen Information

Introduction

ERBB3 is a member of the epidermal growth factor receptor (EGFR/ERBB) family of receptor tyrosine kinases. The kinase-impaired ERBB3 is known to form active heterodimers with other members of the ErbB family, most notably the ligand binding-impaired ErbB2. It is expressed in skin, bone, muscle, nervous system, heart, lungs, and intestinal epithelium. It consists of an extracellular domain, a transmembrane domain, and an intracellular domain. The extracellular domain contains four subdomains (I-IV). Subdomains I and III are leucine-rich and are primarily involved in ligand binding. Subdomains II and IV are cysteine-rich and most likely contribute to protein conformation and stability through the formation of disulfide bonds.

Alternative Names

HER3