GlycoErase™ UGP2 Knockout HEK293 Cell Line (CAT#: GLJF-0825-JF488)

Description	GlycoErase™ UGP2 knockout HEK293 cell line is a HEK293 model with UGP2 removed. UGP2 encodes UDP-glucose pyrophosphorylase, generating UDP-glucose, a central metabolite for glycogen synthesis and glycosylation. The knockout provides a human context to study nucleotide-sugar metabolism, glycogen assembly, and glycosylation control, supporting applications in metabolic disease research, glycoengineering, and biomanufacturing.
Product Type	KO Cell Lines
Species	Human
Cell Morphology	Epithelial-like, adherent
Passage Ratio	1:2~1:4
Cell Line	HEK293
Lineage	Embryonic kidney

Cell Viability	>90%
Sterility Test	The sterility test indicated an absence of microbial growth.
Identity Test	STR identification
Mycoplasma Test	Negative
Virus Test	Negative for HIV, HBV and HCV.
Genetic Stability Testing	We conduct cell genetic stability studies in full compliance with ICH guidelines. Our expertise enables us to design and execute a comprehensive testing program tailored to your specific needs and regulatory requirements.
Validation	PCR, Sanger Sequencing
Culture Medium	FBS & Penicillin/Streptomycin & Proline & RPMI
Application	Functional assay
Size	1 M cells/vial*2
Product Format	Frozen
Shipping	Dry ice
Availability Status	Made to order
Handling Notes	Upon receipt, this product must be immediately transferred from dry ice to liquid nitrogen (-150°C to -190°C) and stored in a liquid nitrogen tank. Cell viability is critically dependent on proper handling. We cannot guarantee viability if these instructions are not strictly adhered to.
Product Disclaimer	This product is provided for research only, not suitable for human or animal use. Due to the inherent limitations of infectious agent testing, investigators must exercise extreme caution when handling cells provided by Creative Biolabs, treating all cells as potentially biohazardous.

Target	UGP2
Full Name	Udp-Glucose Pyrophosphorylase 2
Alternative Name	UDPG; UGP1; DEE83; UDPGP; UGPP1; UGPP2; EIEE83; SVUGP2; UDPGP2; pHC379
Location	2p15
Gene ID	7360
Summary	The encoded enzyme transfers glucose from glucose-1-phosphate to MgUTP, producing UDP-glucose and MgPPi. UDP-glucose is a glycogen precursor in liver and muscle and a lactose precursor in lactating mammary tissue. Eukaryotic and prokaryotic forms are structurally distinct. Two isoforms arise from alternative splicing.