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Recombinant Human CLCF1 protein (NP_001159684.1) is produced in Sia-Increased Human Cell Lines. This expression system is used for the production of glycoproteins with high sialylation and core fucosylation.
This gene is a member of the glycoprotein (gp)130 cytokine family and encodes cardiotrophin-like cytokine factor 1 (CLCF1). CLCF1 forms a heterodimer complex with cytokine receptor-like factor 1 (CRLF1). This dimer competes with ciliary neurotrophic factor (CNTF) for binding to the ciliary neurotrophic factor receptor (CNTFR) complex, and activates the Jak-STAT signaling cascade.