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Recombinant Human FGB protein (NP_001171670.1) is produced in Fuco-Adjusted Human Cell Line. This expression system is used for the production of glycoproteins and antibodies with different fucosylation degrees.
The protein encoded by this gene is the beta component of fibrinogen, a blood-borne glycoprotein comprised of three pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin which is the most abundant component of blood clots. In addition, various cleavage products of fibrinogen and fibrin regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several cell types.