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GlycoErase™ PHKA2 Knockout HepG2 Cell Line

CAT#: GLJF-0825-JF668

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Overview Specification Target Information Related Products
Overview
Description
GlycoErase™ PHKA2 knockout HepG2 cell line removes PHKA2 expression, encoding the hepatic isoform of the phosphorylase kinase alpha subunit. Mutations cause glycogen storage disease type IXA. This knockout is ideal for modeling liver-specific glycogen metabolism, energy regulation, and metabolic liver disease.
Product Type
KO Cell Lines
Species
Human
Cell Morphology
Epithelial-like, adherent
Passage Ratio
1:4~1:6
Cell Line
HepG2
Primary Disease
Hepatoblastoma
Lineage
Liver
Lineage Subtype
Hepatoblastoma
Specification
Cell Viability
>90%
Sterility Test
The sterility test indicated an absence of microbial growth.
Identity Test
STR identification
Mycoplasma Test
Negative
Virus Test
Negative for HIV, HBV and HCV.
Genetic Stability Testing
We conduct cell genetic stability studies in full compliance with ICH guidelines. Our expertise enables us to design and execute a comprehensive testing program tailored to your specific needs and regulatory requirements.
Validation
PCR, Sanger Sequencing
Culture Medium
DMEM & FBS & Glutamine
Application
Functional assay
Size
1 M cells/vial*2
Product Format
Frozen
Shipping
Dry ice
Availability Status
Made to order
Handling Notes
Upon receipt, this product must be immediately transferred from dry ice to liquid nitrogen (-150°C to -190°C) and stored in a liquid nitrogen tank. Cell viability is critically dependent on proper handling. We cannot guarantee viability if these instructions are not strictly adhered to.
Product Disclaimer
This product is provided for research only, not suitable for human or animal use. Due to the inherent limitations of infectious agent testing, investigators must exercise extreme caution when handling cells provided by Creative Biolabs, treating all cells as potentially biohazardous.
Target Information
Target
PHKA2
Full Name
Phosphorylase Kinase Regulatory Subunit Alpha 2
Alternative Name
PHK; PYK; XLG; PYKL; XLG2; GSD9A
Location
Xp22.13
Gene ID
5256
Summary
Phosphorylase kinase is assembled from 16 total subunits-four each of alpha, beta, gamma, and delta types. In this form, the hepatic alpha isoform is produced by this gene, while the gamma unit hosts the catalytic site. The delta subunit is a calmodulin that manages calcium dependence. Variants in this gene cause glycogen storage disease type 9A. Several splice forms have been detected but remain incompletely characterized.
For Research Use Only.
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