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Recombinant human SERPINA1 protein (NP_000286.3) is produced in Sia-Increased Human Cell Lines. This expression system is used for the production of glycoproteins with high sialylation and core fucosylation.
The protein encoded by this gene is secreted and is a serine protease inhibitor whose targets include elastase, plasmin, thrombin, trypsin, chymotrypsin, and plasminogen activator. Defects in this gene can cause emphysema or liver disease. Several transcript variants encoding the same protein have been found for this gene.
Alternate Names
Alpha-1 protease inhibitor; Alpha-1-antiproteinase; Serpin A1 [Cleaved into: Short peptide from AAT; SPAAT]; SERPINA1; AAT; PI; PRO0684; PRO2209