Recombinant Human SERPINC1 Protein, Glycoengineered Mannose-5 Pichia pastoris

Recombinant human SERPINC1 protein (NP_000479.1) is produced in Glycoengineered Mannose-5 Pichia pastoris. This expression system is used for the production of glycoproteins and antibodies with a mannose-5 structure at N-linked sites.

Glycoengineered Mannose-5 Pichia pastoris

Human

His-tag, FC-tag

>90%, determined by SDS-PAGE.

Regular batch

None

SERPINC1

Antithrombin-III

The protein encoded by this gene is a plasma protease inhibitor and a member of the serpin superfamily. This protein inhibits thrombin as well as other activated serine proteases of the coagulation system, and it regulates the blood coagulation cascade. The protein includes two functional domains: the heparin binding-domain at the N-terminus of the mature protein, and the reactive site domain at the C-terminus. The inhibitory activity is enhanced by the presence of heparin. More than 120 mutations have been identified for this gene, many of which are known to cause antithrombin-III deficiency.

ATIII; Serpin C1; SERPINC1; AT3; PRO0309