Ionizable lipid C12-113

C12-113 is a proprietary ionizable lipid designed for the optimized formulation of lipid nanoparticles (LNPs), which are engineered for efficient intracellular delivery of RNA cargo. C12-113 LNPs have been shown to facilitate the effective delivery of mRNA encoding luciferase and the SARS-CoV-2 spike protein into target cells. This demonstrates the lipid's capability to protect and release sensitive genetic material, providing a robust tool for developing mRNA vaccines and protein replacement therapies.

1220890-27-6

1-[2-[2-[Bis(2-hydroxydodecyl)amino]ethyl-methylamino]ethyl-(2-hydroxydodecyl)amino]dodecan-2-ol; BP-41394; CS-1009295

C₅₃H₁₁₁N₃O₄

854.5

InChI=1S/C53H111N3O4/c1-6-10-14-18-22-26-30-34-38-50(57)46-55(47-51(58)39-35-31-27-23-19-15-11-7-2)44-42-54(5)43-45-56(48-52(59)40-36-32-28-24-20-16-12-8-3)49-53(60)41-37-33-29-25-21-17-13-9-4/h50-53,57-60H,6-49H2,1-5H3

LVXMNISFCHVOGG-UHFFFAOYSA-N

Min 95%

Dried by centrifugal evaporation from a solution.

Conforms to structure

Store at -20°C for long term storage.