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GlycoFlux™ MMLV-Human SIGLEC2 Viral Particle

CAT#: GLJF-1025-JF361

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SPECIFIC INQUIRY
Antibiotic Resistance:
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Titer:
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Specifications Quality Control Target Information Related Products
Specifications
Description
GlycoFlux™ MMLV-SIGLEC2 Viral Particle encodes SIGLEC2 (CD22), a B-cell inhibitory receptor regulating BCR signaling and endocytosis; this MMLV platform enables stable expression in mammalian cells to interrogate B-cell checkpoints, trafficking, and therapeutic targeting mechanisms.
Product Type
Recombinant MMLV Retrovirus
Target
SIGLEC2
Species
Human
Promotor
MMLV 5' LTR promoter
Packaging System
Retrovirus
Packaging Cell
HEK293T
Application
This MMLV vector is a common retroviral vector system that permanently integrates a gene into the host cell's genome, allowing for long-term, sustained expression. It is a popular tool for gene manipulation in dividing cells and for generating iPS cells in biomedical research.
Shipping
Shipped on dry ice with temperature held at or below -80°C.
Storage
Store at -80°C to maintain their titer and stability.
Handling Notes
Store products at -80°C, and avoid repeated freeze-thaw cycles to maintain viral titer. For safety, always handle the products in a biological safety cabinet, using appropriate personal protective equipment like lab coats, gloves, and eye protection.
Product Disclaimer
These products are for research use only and not for diagnostic or clinical use. The user assumes full responsibility for all safety protocols and compliance with relevant regulations. While we are committed to quality, Creative Biolabs makes no guarantee as to the performance of these products in a specific application.
Quality Control
Titer Assay
qPCR
Mycoplasma Test
Negative
Sterility
Sterility testing confirmed no microbial contamination.
Transduction Evaluation
On request, Creative Biolabs conducts in vitro or in vivo transduction assays to evaluate lentiviral delivery to target cells and to quantify transgene expression and function.
Insert Identity Confirmation
Creative Biolabs verifies all retroviral vectors by a PCR-based proviral integration check. In brief, cells are transduced with serial dilutions of the retroviral preparation and, after several days, genomic DNA is extracted. A predefined segment of the expected retroviral insert is then amplified by PCR to confirm correct identity and integration.
Target Information
Full Name
Sialic Acid Binding Ig Like Lectin 2
Alternative Name
SIGLEC-2; CD22; Sialic Acid Binding Ig Like Lectin
Location
19q13.12
Gene ID
8778
Summary
The protein is predicted to have activities such as binding to CD4 receptors, protein phosphatases, and sialic acid. It plays a role in activating B cells, negatively regulating the B cell receptor signaling pathway, and controlling endocytosis. The protein is localized in early and recycling endosomes and has been implicated in the development of diffuse large B-cell lymphoma.
For Research Use Only.
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