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Recombinant Human CRTAP protein (NP_006362.1) is produced in Glycoengineered Mannose-5 Pichia pastoris. This expression system is used for the production of glycoproteins and antibodies with a mannose-5 structure at N-linked sites.
The protein encoded by this gene is similar to the chicken and mouse CRTAP genes. The encoded protein is a scaffolding protein that may influence the activity of at least one member of the cytohesin/ARNO family in response to specific cellular stimuli. Defects in this gene are associated with osteogenesis imperfecta, a connective tissue disorder characterized by bone fragility and low bone mass.
Alternate Names
Cartilage Associated Protein; Prolyl 3-Hydroxylase Family Member 5 (Non-Enzymatic); Leprecan-Like 3; CASP; LEPREL3; P3H5; OI7